Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy

Aim. To compare changes in the complement system C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after relief of an acute episode thrombotic microangiopathy.
 Materials methods. The study included 8 patients diagnosed with C3-GP aHUS remission. blood levels components were determined: C3, C4, C3a, C5a, factor H (CFH), B (CFB), membrane-attacking complex (MAC), antibodies to C3b (anti-C3b-AT), level activity (CH50), content D (CFD) urine.
 Results. C3 CH50 within reference range both groups, however, group they at lower limit, was significantly than group: 0.56 [0.44; 0.96] vs 1.37 [1.16; 2.52] (p=0.003). CFB increased detected but it 275.1 [222.1; 356.6] 438.7 [323.3; 449.3] (p=0.010). C5a MAC maximum group, 2 times higher that aHUS, these differences reached statistical significance 123 5556686 56031294 (p=0.036). CFH CFD their highest values group.
 Conclusion. Alternative pathway activation signs present groups complement-mediated nephropathies, regardless stage disease. In C3-GP, alternative more pronounced microangiopathy.